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A cocktail of 165 Er(iii) and Gd(iii) complexes for quantitative detection of zinc using SPECT and MRI.

Kyangwi P Malikidogo, Isidro Da Silva, Jean-François Morfin, Sara Lacerda, Laurent Barantin, Thierry Sauvage, Julien Sobilo, Stéphanie Lerondel, Éva Tóth, Célia S Bonnet
Chemical Communications : Chem Comm 2018 July 6
We propose quantitative assessment of zinc by combining nuclear and MR imaging. We use a cocktail of a Gd3+-complex providing a Zn2+-dependent MRI response and its 165Er3+ analogue allowing for concentration assessment. 165Er is readily obtained in a cyclotron and purified, which is indispensable for successful quantification of metal ions.

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