We have located links that may give you full text access.
CLINICAL TRIAL
JOURNAL ARTICLE
Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study.
Objective: The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children and adolescents with idiopathic short stature (ISS).
Methods: A cross-sectional study of 91 Chinese children and adolescents with ISS was performed. Anthropometric measurements and biochemical parameters were tested. The standard deviation score of IGF-1 (IGF-1 SDS) was calculated.
Results: A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA ( P = 0.004). In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 μ mol/L and 301 μ mol/L ( β 0.010, 95% CI 0.004-0.017; P = 0.002). The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 μ mol/L ( β -0.055, 95% CI -0.081--0.028; P < 0.001) or more than 301 μ mol/L ( β -0.005, 95% CI -0.013-0.002; P = 0.174).
Conclusions: This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect.
Methods: A cross-sectional study of 91 Chinese children and adolescents with ISS was performed. Anthropometric measurements and biochemical parameters were tested. The standard deviation score of IGF-1 (IGF-1 SDS) was calculated.
Results: A univariate analysis displayed a significant positive correlation between IGF-1 SDS and UA ( P = 0.004). In multivariate piecewise linear regression, the levels of IGF-1 SDS increased with the elevation of UA when UA was between 168 μ mol/L and 301 μ mol/L ( β 0.010, 95% CI 0.004-0.017; P = 0.002). The levels of IGF-1 SDS decreased with the elevation of UA when UA was either less than 168 μ mol/L ( β -0.055, 95% CI -0.081--0.028; P < 0.001) or more than 301 μ mol/L ( β -0.005, 95% CI -0.013-0.002; P = 0.174).
Conclusions: This study demonstrated a nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS. This finding suggests that either high or low levels of UA may have an adverse effect on IGF-1, whereas appropriate UA levels have a beneficial effect.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app