[Influence of basic dental materials on indicators of free radical oxidation and antioxidant blood`s potential of white rats (experimental study)].

OBJECTIVE: Introduction: Basic materials used in the clinic of orthopedic dentistry are high-polymer compounds and have a number of positive properties in certain conditions. The main group of materials for manufacturing of removable dentures is acrylic plastics of hot polymerization. However, such materials can sometimes cause a number of complications. Using removable prostheses, which are made of acrylic plastics can cause the development of an allergic or toxic-chemical reaction of tissues of the prosthetic bed. The question of improving the quality of removable prosthesis is one of the most important problems for many years because of reactions of people's organism they can cause. This aim is achieved by development of new basic dental materials and improvements at various stages of the process of manufacturing removable plate prostheses. The aim: To investigate the possible adverse effect of various groups of basic dental materials on some hematological parameters of white male rats in the Wistar line.

PATIENTS AND METHODS: Materials and methods: Experiments were performed on 20 white male Wistar rats weighing 160-200 grams. The choice of this species was based on the literature data on the use of white rats in the study of the biological effects of plastics, solvents, dyes, and others. Freshly made samples of the studied materials were used in experiments, because the maximum allocation of monomer occurs in the first 7 days after polymerization. Euthanasia of animals was performed 7 days after surgical intervention under hexenal anesthesia by blood transfusion from the right ventricle. The object of the study was the venous blood of experimental animals.

RESULTS: Results: On the seventh day after substrate samples of basic materials Ftorax, Deflex Acrylato and Vertex ThermoSens intramuscularly into the anterior abdominal wall, white laboratory rats did not have results, such as some unnormal reaction of the animal's organism. A slight increase in the value of the index of spontaneous hemolysis of erythrocytes (5.8±0.5%) in the group of animals, which was sampled with the material "Ftorax" in comparison with the control group (4.6±0.3%), has no statistically significant difference. Similarly, there is no significant increase in the accumulation of TBC-reactants in this group to a value of 4.48±0.28 μmol/l compared with the group of pseudo-operated animals (3.02±0.41 μmol/l), which is not statistically significant. Thus, it can be stated that according to the parameters of free radical oxidation, the biological reaction of the animal organism to the incorporation of the aforementioned materials was not revealed.

CONCLUSION: Conclusions: The results of the study of the biological effect of basic dental plastics on white rats by stacking samples of investigated material into the anterior abdominal wall evaluated by free radical oxidation and activity of antioxidant enzymes did not reveal statistically significant differences comparing with the control group of animals.