The changes of some bioregulators and gas transmitters in patients with hypertonic disease under the influence of physical loading.

OBJECTIVE: Introduction: Nowadays arterial hypertension is supposed to be a pathogenetic factor of numerous cardiovascular diseases (CVD) and 18% cases of the preterm death. Due to the data of the American Heart Association in 77% of patients, who had stroke, the arterial pressure overexceeded 140/90 mm Hg. In Ukraine, according to the epidemiologic study more than 1/3 of the population have increased arterial pressure. One of the extremely important aspects of struggle with CVD is diagnosis and prevention of hypertonic disease. The prevalence of arterial hypertension worldwide increases averagely for 3-4% per year that corresponds with the level of a true epidemy. The aim: Was to evaluate nitrosooxidative status, content of hydrogen sulphide and cortisol in blood serum of patients with a II stage arterial hypertension under the conditions of physical loading.

PATIENTS AND METHODS: Materials and methods: 30 patients with II stage arterial hypertension were examined. Examined patients were exposed to two-stage physical loading using veloergometer with the intensity relevant to 50 and 75 % of the proper maximal oxygen uptake (MOU) of the body.

RESULTS: Results: In blood serum of patients before and after physical loading the content of TBA-active products, hydrogen sulphide, L-arginine, nitric anion, sum of nitrite-nitrate, cortisol, activity of SOD, catalase and arginase were determined. Significant increase of L-arginine and hydrogen sulphide on the background of the decrease of nitrite-anion and sum of nitrite-nitrate was noted. It may be suggested that in individuals with hypertonic disease under the influence of physical loading synthesis of NO decreases and vasodilatation and vasoprotection occur by means of increase of the hydrogen sulphide level.

CONCLUSION: Conclusions: The indices of L-arginine, nitrite-anion and Н2S in blood serum after physical loading reflect the changes in the system of vasodilatation in patients with arterial hypertension. The parameters of gaseous messengers NO and Н2S are the fastest to react to veloergometry on the background of insignificant changes of the level of cortisol, activity of arginase, SOD and catalase in patients with II stage hypertonic disease. Increase of the level of L-arginine and hydrogen sulphide as well as decrease of nitrite-anion level may be considered to be markers of evaluation of immediate changes in patients with arterial hypertension after physical loading.