[Effects of highly selective branches neurotomy of vidian nerve with low temperature plasma on vasoactive intestinal peptide in nasal mucosal cells of patients with allergic rhinitis].

Objective: The aim of this study is to investigate the effect of highly selective branches neurotomy of vidian nerve with low temperature plasma on the level of vasoactive intestinal peptide in nasal mucosa of patients with allergic rhinitis. Method: Fifty patients with allergic rhinitis were selected as the experimental group. At the same time, 50 normal adults in our hospital were selected as the control group. Highly selective branches neurotomy of vidian nerve with low temperature plasma was performed to observe the changes of vascular intestinal peptide levels in patients with nasal mucosa and the clinical efficacy. Result: Fifty patients with allergic rhinitis were treated with highly selective branches neurotomy of vidian nerve with low temperature plasma. 28 cases have significant effect and the curative effect was 64.3%-92.1% (average was 77.4±4.5)%; 19 were effective and the therapeutic effect was 31.2%-56.4%, with an average of (43.2±2.9)%; only 3 cases were ineffective, and the therapeutic effect was less than 30%. There was significant difference between the two groups after treatment ( P <0.05). The optical density of vasoactive intestinal peptide was (1 723.3±215.4) and (2 732.3±324.5) in the preoperative and postoperative groups, respectively, with significant differences ( P <0.05). The optical density of vasoactive intestinal peptide in the control group was (1 855.4±429.3), which was significantly different from that in the experimental group before operation ( P <0.05). The difference between the control group and the experimental group after operation have no statistically significant ( P >0.05). Conclusion: Highly selective branches neurotomy of vidian nerve with low temperature plasma can significantly reduce the level of vasoactive intestinal peptide in nasal mucosa of patients with allergic rhinitis, alleviate the symptoms of nasal congestion and paroxysmal sneezing, and improve the prognosis of patients.