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EB1 traps STIM1 and regulates local store-operated Ca 2+ entry.

Qiao-Chu Wang, Xi Wang, Tie-Shan Tang
Journal of Cell Biology 2018 June 5
STIM1 activates store-operated Ca2+ entry when Ca2+ in the endoplasmic reticulum (ER) is depleted. In this issue, Chang et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201711151) demonstrate that EB1 traps STIM1 at dynamic contacts between the ER and microtubule plus ends, delaying STIM1 translocation to ER-plasma membrane junctions and preventing Ca2+ overload.

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