Dextroamphetamine sulfate provided quick relief of severe post-partum depression that was recalcitrant to standard antidepressants and psychotherapy.

PURPOSE: To determine if dextroamphetamine sulfate could improve symptoms of post-partum depression.

MATERIALS AND METHODS: A woman with severe post-partum depression that was resistant to standard antidepressant therapy and psychotherapy was treated with dextroamphetamine sulfate extended release capsules 15 mg/day.

RESULTS: A quick and complete abrogation of the depression ensued along with improvement of migraine headaches, insomnia, and chronic fatigue.

CONCLUSIONS: Dextr6amphetamine sulfate should be considered as a treatment modality for post-partum depression.