Research on the correlation between ultrasonographic features of breast cancer and expressions of ER, CD34 and p53.

PURPOSE: To investigate the expressions of estrogen receptor (ER), highly glycosylated type I transmembrane glycoprotein (CD34) and p53 in breast cancer tissue and analyze their correlation with color Doppler ultrasonographic features.

METHODS: 86 patients who were admitted to our hospital with confirmed breast cancer diagnosis from January 2016 to December 2016 were selected. The expressions of ER, CD34 and p53 in cancer tissue and corresponding canceradjacent normal tissue were detected by immunohistochemical staining, and the color Doppler ultrasonographic features of patients were observed and analysed by Spearman correlation test.

RESULTS: The positive rates of ER, CD34 and p53 expressions in cancer tissue of the case group were 46.5, 50 and 52.3%, respectively, significantly higher than 1.7% of the control group (p<0.05). The expressions of ER, CD34 and p53 in the cancer tissue of case group were correlated with the existence of calcification, spicule sign and lymph node metastasis detected by Doppler ultrasound (p<0.05), but not associated with tumor diameter and morphology (p>0.05). Spearman correlation test indicated positive correlation between expressions of ER and CD34 in cancer tissue of the case group (r=0.703, p<0.05); ER expression was positively associated with p53 expression (r=0.716, p<0.05) and CD34 expression was positively related to p53 expression (r=0.684, p<0.05).

CONCLUSIONS: The expressions of ER, CD34 and p53 have significant roles in the occurrence and development of breast cancer. There is a certain correlation between expressions of ER, CD34 and p53 of breast cancer and color Doppler ultrasonographic features. The expression levels of ER, CD34 and p53 in breast cancer tissue can be evaluated by color Doppler ultrasonographic features, which is conducive to assessing the prognosis of these patients.