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Journal Article
Review
Mechanism of N 6 -methyladenosine modification and its emerging role in cancer.
Pharmacology & Therapeutics 2018 September
N6 -methyladenosine (m6 A), the most prevalent internal methylation in messenger RNA (mRNA) that is deposited by m6 A methyltransferases, removed by m6 A demethylases and recognized by different RNA-binding proteins, distinguishes the transcripts through multilayer interactions with mRNA processing, export, degradation and translation machineries. m6 A plays an important role in regulation of gene expression for fundamental cellular processes and diverse physiological functions. Aberrant m6 A decorations lead to cancer but also have the potential to yield new therapies. This review outlines the evolution of the m6 A field, formation of key concepts, important open questions and also discusses the molecular basis of mRNA m6 A modification and its effect in cancer, highlighting the potential of demethylase as a therapeutic target for cancer treatment.
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