Changes in cholecystokinin level in patients with gastroesophageal reflux disease on the background of type II diabetes.

OBJECTIVE: Introduction: The question of the combination and combined influence of the gastroesophageal reflux disease (GERD) and many other chronic diseases of internal medicine, including diabetes, have not been studied enough. The aim: To investigate the changes in cholecystokinin (CCK) levels in blood serum of patients with GERD on the background of type II diabetes.

PATIENTS AND METHODS: Materials and methods: On the basis of the propaedeutics of internal diseases department of the medical faculty of the SHEI "UzhNU" during the period of 2016 - 2017, 48 patients were examined for type II diabetes with GERD (main group: group I). The comparison group comprised 18 patients with GERD (group II). All of the patients had their blood serum cholecystokinin levels examined with the help of enzyme-linked immunosorbent assay (ELISA) using the test system of the "Peninsula Laboratories" (USA) company.

RESULTS: Results: The gathered data points to an increase of the CCK levels in blood serum in patients with GERD, as compared to the indices of the control group. This being said, we can highlight that in patients with the background of combined pathology, type II diabetes and GERD in particular, the level of CCK exceeds the average by 6 times, whereas in patients with GERD (comparison group) it exceeds only by 2.4 times. Further analysis of the gathered results points out an interesting pattern in the changes of blood serum CCK levels in patients with GERD on the background of type II diabetes depending on the BMI, in particular - the maximal indices were observed in patients with excess body weight.

CONCLUSION: Conclusions: In patients with GERD an increase of CCK level is observed, as compared to the indices of healthy individuals. The combination of GERD and type II diabetes is accompanied by a more prominent increase of CCK in blood serum, with a correlation between the disorder of the nutritional status and the CCK level had been established, namely - its maximal indices in patients with excess body weight.