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Activation of the rat olfactory bulb by direct ventral stimulation after nerve transection.

BACKGROUND: The aim of this study was to demonstrate how direct electrical stimulation can activate the olfactory bulb after denervation of the olfactory nerve input.

METHODS: Sprague-Dawley rats (n = 5) were anesthetized and olfactory bulbs exposed. Olfactory nerves were transected by passing a Teflon blade between the cribriform plate and ventral surface of the bulb. A cochlear implant electrode array was used to stimulate 6 different positions along the ventral surface of the olfactory bulb. Biphasic constant-current pulses were used (50-1000 μA, 50-1000 μs) to stimulate the bulb, and a 16-electrode paddle array was used to record localized negative field potential responses at the dorsal surface of the bulb.

RESULTS: Localized negative field potentials were reliably obtained using biphasic, 500-μA, 200-μs pulses. A shift in stimulating position by 1 mm resulted in a significant change in the dorsal field potential.

CONCLUSION: Direct stimulation of the deafferented olfactory bulb was effective in generating localized field potential responses. These findings support the potential use of direct electrical stimulation for the treatment of anosmia.

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