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A short synthesis of Dronedarone.
Bioorganic & Medicinal Chemistry 2018 August 8
A modification of the Nenitzescu reaction was used to obtain Dronedarone from quinonimine 20 and 1,3-diketone 14 (R = CH2 CH2 CH2 NBu2 ) in a two-stage process in almost 55% overall yield. Our results represent significant improvement over other state-of-the-art methods as no extra steps for the decoration of the benzofuran core are required.
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