We have located links that may give you full text access.
Sodium butyrate abolishes the degradation of type II collagen in human chondrocytes.
Biomedicine & Pharmacotherapy 2018 June
Excessive expression of matrix metalloproteinases (MMPs) induced by pro-inflammatory cytokines such as interleukin-1β (IL-1β) has been associated with destruction of the articular cartilage matrix in chondrocytes from patients with osteoarthritis (OA). Among the MMPs, MMP-1, MMP-3 and MMP-13 participate in the degradation of type II collagen, the main component of the extracellular matrix in articular cartilage. Sodium butyrate is a bacterial metabolite used in the treatment of inflammatory diseases. However, the effects of sodium butyrate on the expression of MMPs and degradation of type II collagen has not been explored. In the current study, for the first time, we aimed to determine whether sodium butyrate influences IL-1β-induced degradation of type II collagen in human chondrocytes in the articular cartilage matrix. Our results indicate that sodium butyrate significantly abrogated IL-1β-induced up-regulation of MMP-1, MMP-3, and MMP-13 at both the gene and protein levels. In addition, treatment with sodium butyrate suppressed expression of the endogenous tissue inhibitors TIMP-1 and TIMP-2. Notably, sodium butyrate attenuated IL-1β-induced degradation of type II collagen. Mechanistically, we found that sodium butyrate abolished the activation of NF-κB by inhibiting phosphorylation of IKK, IκBα, and NF-κB p65. Based on these observations, we conclude that butyrate may have potential as a therapeutic agent for OA.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian Journal of Anaesthesia 2024 April 11
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app