Feasibility and implementation of CYP2C19 genotyping in patients using antiplatelet therapy.

Thomas O Bergmeijer, Gerrit Ja Vos, Daniël Mf Claassens, Paul Wa Janssen, Remko Harms, Richard van der Heide, Folkert W Asselbergs, Jurriën M Ten Berg, Vera Hm Deneer

Pharmacogenomics 2018 May

AIM: A tailored antiplatelet strategy based on CYP2C19 genotype may reduce atherothrombotic and bleeding events. We describe our experience with CYP2C19 genotyping, using on-site TaqMan or Spartan genotyping or shipment to a central laboratory.

METHODOLOGY: Data from two ongoing projects were used: Popular Risk Score project (non-urgent percutaneous coronary intervention patients) and the Popular Genetics study (ST-segment elevation myocardial infarction patients). For both projects, the time to genotyping result was calculated.

RESULTS: In the Popular Risk Score project (n = 2556), median time from blood collection to genotyping result was 4:04 h. In the Popular Genetics study (n = 1038), median time from randomization to genotyping result was 2:24 h.

CONCLUSION: CYP2C19 genotyping is feasible in everyday clinical practice, both in the acute and non-acute settings.

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