MiR-150 suppresses tumor growth in melanoma through downregulation of MYB.

MiR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal cancer, ovarian cancer and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cell lines. Through transfection of miR-150 mimics, we found that miR-150 significantly inhibited the proliferation, migration and invasion of melanoma cells. In mechanism, we found that MYB was a target of miR-150 in melanoma cells. Overexpression of miR-150 significantly inhibited mRNA and protein levels of MYB in melanoma cells. Moreover, there was an inversely correlation between the expression of miR-150 and MYB in melanoma tissues. We also showed that MYB was upregulated in melanoma tissues and cell lines. Through functional experiments, we found that restoration of MYB in miR-150-overexpressed melanoma cells rescued the proliferation, migration and invasion. Therefore, our findings demonstrated that miR-150 suppressed the proliferation, migration and invasion of melanoma cell by downregulating MYB.