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Autophagosome Formation: Cutting the Gordian Knot at the ER.
Current Biology : CB 2018 April 24
Autophagosome biogenesis and the origins of its isolation membrane have been a long-standing unresolved question, with the endoplasmic reticulum and its membrane contact sites with other organelles remaining the prime suspect. This concept has now been reinforced by recent advances uncovering roles of several ER membrane proteins in autophagosome formation.
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