Add like
Add dislike
Add to saved papers

Correlation analysis of CD4 gene polymorphism and blood routine Indexes in pigs (Sus scrofa).

Cluster of differentiation 4 (CD4) is an important molecule in the immune system of animals, which participates in the processes of T-lymphocyte differentiation, maturation, immune response and signal transduction. During this study, we adopted the direct sequencing of PCR products and time-of-flight mass spectrometry methods for the detection of single nucleotide polymorphisms (SNPs) in 382 Yorkshire pigs. The linkage disequilibrium of CD4 gene polymorphisms and their genetic effects on blood routine indexes were also analyzed. The results showed that SNP was screened in intron 1, intron 6 and exon 10, respectively, of the porcine CD4 gene, and each SNP locus was detected in Yorkshire pigs, which had three genotypes with moderate polymorphism. The three SNPs were in strong linkage disequilibrium (r2>0.8), and constituted only two major haplotypes, AGT and CAC (both frequencies accounted for about 97%). The association analysis showed that CD4 gene polymorphisms were significantly correlated with white blood cell, lymphocyte and monocyte count in Yorkshire pigs (P less than 0.05). The white blood cell count and monocyte count in individual animals with CAC/CAC diplotype were significantly higher than those with AGT/CAC and AGT/AGT diplotypes (P less than 0.05). The lymphocyte count in animals with CAC/CAC diplotype were significantly higher than those with the AGT/AGT diplotype (P less than 0.05). This study indicates that CD4 gene is significantly associated with partial blood routine indexes in pigs, and it can be considered as a candidate gene for the study of porcine disease resistance.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app