A Mechanosensitive GPCR that Detects the Bloody Force.

Adam J Iliff, X Z Shawn Xu

Cell 2018 April 20

Mechanoreceptors mediate a wide variety of physiological processes, such as hearing, touch, proprioception, and blood flow regulation. It is generally believed that mechanoreceptors are force-gated ion channels. Now, Xu et al. uncover a GPCR that is activated by shear force in endothelial cells of blood vessels.

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A Mechanosensitive GPCR that Detects the Bloody Force.

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