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Heavy Alcohol Use Among Deceased Donors Does Not Impact Recipient Outcomes After Liver Transplantation.
Transplantation 2018 April 20
BACKGROUND: Data on liver transplant (LT) outcomes using deceased donors with heavy drinking (HD) (>2 drinks/day) are scanty.
METHODS: Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with not heavy drinking (ND) donors.
RESULTS: Of 56 182 first LTs performed in the US for 10 common indications using deceased donors, 47 882 with available information on alcohol use were analyzed. Of these 47 882 LT recipients, 7 298 (15%) were from HD donors, with similar proportion over time (2002-2014, Armitage trend test P=0.75) and for recipient liver disease etiology (Chi square P=0.42). Proportion of liver organ used for LT was lower for HD donors compared to ND donors (63 vs. 78%, P<0.001). Five-year outcomes on first LT comparing 7 166 HD donors and 21,498 ND donors matched based on propensity score, were similar for liver graft (73.7 vs. 73.7%, Log Rank P=0.98), and patient survival (77.6 vs. 77.0%, P=0.36). On Cox regression analysis, history of HD in deceased donors did not affect liver graft 1.02 (0.97-1.08) or patient survival 1.03 (0.97-1.09).
CONCLUSION: Among LT recipients using select liver grafts, history of HD in deceased donors does not impact outcomes after LT.
METHODS: Using the United Network for Organ Sharing database (2002-2014), we examined outcomes after LT in adults comparing deceased HD donors with not heavy drinking (ND) donors.
RESULTS: Of 56 182 first LTs performed in the US for 10 common indications using deceased donors, 47 882 with available information on alcohol use were analyzed. Of these 47 882 LT recipients, 7 298 (15%) were from HD donors, with similar proportion over time (2002-2014, Armitage trend test P=0.75) and for recipient liver disease etiology (Chi square P=0.42). Proportion of liver organ used for LT was lower for HD donors compared to ND donors (63 vs. 78%, P<0.001). Five-year outcomes on first LT comparing 7 166 HD donors and 21,498 ND donors matched based on propensity score, were similar for liver graft (73.7 vs. 73.7%, Log Rank P=0.98), and patient survival (77.6 vs. 77.0%, P=0.36). On Cox regression analysis, history of HD in deceased donors did not affect liver graft 1.02 (0.97-1.08) or patient survival 1.03 (0.97-1.09).
CONCLUSION: Among LT recipients using select liver grafts, history of HD in deceased donors does not impact outcomes after LT.
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