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Clinical efficacy of combined topical 0.05% cyclosporine A and 0.1% sodium hyaluronate in the dry eyes with meibomian gland dysfunction.
AIM: To investigate the efficacy of combined topical 0.05% cyclosporine A (CsA; Restasis® , Allergan pharmaceuticals, USA) and 0.1% sodium hyaluronate treatment in dry eyes with meibomian gland dysfunction (MGD).
METHODS: In a retrospective analysis, 53 patients (106 eyes) with MGD were enrolled and performed lid warm massage for 10min daily and be instilled preservative free sodium hyaluronate 0.1% eye drops 4 times daily. Patients were divided into subjects treated with topical 0.05% CsA and preservative free sodium hyaluronate vehicle (experimental group, n =74 eyes) and subjects treated with the preservative free sodium hyaluronate vehicle (control group, n =32 eyes). They were evaluated at baseline and 1, 2, and 3mo for subjective symptoms and objective signs including tear film break-up time (tBUT), Schirmer test, corneal staining (CS) score, lid margin telangiectasia (LMT), meibomian gland secretion (MGS), and conjunctival injection (CI).
RESULTS: In the short-term treatment, the experimental group showed a statistically significant improvement in the ocular surface disease index (OSDI; P <0.001), tBUT ( P =0.004), Schirmer test score ( P =0.008) and LMT ( P =0.021) by repeated measure ANOVA. Additionally, mean changes from baseline in OSDI ( P <0.001), tBUT ( P =0.001), Schirmer test score ( P =0.029), CS score ( P =0.047), LMT ( P =0.002), CI ( P =0.030) were improved better in the experimental group than in the control group at 3mo. However, there was no significant difference between the two groups in MGS ( P =0.67).
CONCLUSION: In dry eyes with MGD, 0.05% CsA improves the tear film stability as well as subjective ocular discomfort, and is effective in controlling lid margin inflammation.
METHODS: In a retrospective analysis, 53 patients (106 eyes) with MGD were enrolled and performed lid warm massage for 10min daily and be instilled preservative free sodium hyaluronate 0.1% eye drops 4 times daily. Patients were divided into subjects treated with topical 0.05% CsA and preservative free sodium hyaluronate vehicle (experimental group, n =74 eyes) and subjects treated with the preservative free sodium hyaluronate vehicle (control group, n =32 eyes). They were evaluated at baseline and 1, 2, and 3mo for subjective symptoms and objective signs including tear film break-up time (tBUT), Schirmer test, corneal staining (CS) score, lid margin telangiectasia (LMT), meibomian gland secretion (MGS), and conjunctival injection (CI).
RESULTS: In the short-term treatment, the experimental group showed a statistically significant improvement in the ocular surface disease index (OSDI; P <0.001), tBUT ( P =0.004), Schirmer test score ( P =0.008) and LMT ( P =0.021) by repeated measure ANOVA. Additionally, mean changes from baseline in OSDI ( P <0.001), tBUT ( P =0.001), Schirmer test score ( P =0.029), CS score ( P =0.047), LMT ( P =0.002), CI ( P =0.030) were improved better in the experimental group than in the control group at 3mo. However, there was no significant difference between the two groups in MGS ( P =0.67).
CONCLUSION: In dry eyes with MGD, 0.05% CsA improves the tear film stability as well as subjective ocular discomfort, and is effective in controlling lid margin inflammation.
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