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Proton-decoupled carbon magnetic resonance spectroscopy in human calf muscles at 7 T using a multi-channel radiofrequency coil.
Scientific Reports 2018 April 19
13 C magnetic resonance spectroscopy is a viable, non-invasive method to study cell metabolism in skeletal muscles. However, MR sensitivity of 13 C is inherently low, which can be overcome by applying a higher static magnetic field strength together with radiofrequency coil arrays instead of single loop coils or large volume coils, and 1 H decoupling, which leads to a simplified spectral pattern. 1 H-decoupled 13 C-MRS requires RF coils which support both, 1 H and 13 C, Larmor frequencies with sufficient electromagnetic isolation between the pathways of the two frequencies. We present the development, evaluation, and first in vivo measurement with a 7 T 3-channel 13 C and 4-channel 1 H transceiver array optimized for 1 H-decoupled 13 C-MRS in the posterior human calf muscles. To ensure minimal cross-coupling between 13 C and 1 H arrays, several strategies were combined: mutual magnetic flux was minimized by coil geometry, two LCC traps were inserted into each 13 C element, and band-pass and low-pass filters were integrated along the signal pathways. The developed coil array was successfully tested in phantom and in vivo MR experiments, showing a simplified spectral pattern and increase in signal-to-noise ratio of approximately a factor 2 between non-decoupled and 1 H-decoupled spectra in a glucose phantom and the human calf muscle.
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