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A concise total synthesis of cochlearoid B.
Organic & Biomolecular Chemistry 2018 May 10
A T-type calcium channel inhibiting natural product cochlearoid B was synthesized for the first time in 7 linear steps via a convergent strategy exploiting the Suzuki-Miyaura cross coupling and the acid promoted Prins cyclization cascade. This strategy allows rapid access to its structural analogues for further therapeutical development.
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