The usefulness of determination of the procalcitonin (PCT) concentration in GBS piositive pregnant womens blood serum for anticipations of infections in newborns

Group-B streptococci (GBS) are commensal bacteria of the human body. They may, however, pose a serious life hazard to pregnant women. During labour, newborns of GBS-positive mothers run the risk of infections that may eventually lead to severe complications, sepsis or even death. For this reason, it is very important to find new diagnostic markers that will enable fast and effective diagnostics and control of the disease process. The level of procalcitonin emerges as a promising diagnostic parameter. AIM. Analysis of the impact of the procalcitonin (PCT) level in GBS-positive pregnant women on the possibility of complications and infections in mothers and newborns MATERIAL AND METHODS. The study group consisted of 115 GBS-positive pregnant women. For each mother-to-be, the CRP and the PCT concentration levels were determined. The clinical state of 117 newborns (2 twin pregnancies) was also assessed. After delivery, the CRP concentration level was determined in the newborns. The examinations had a retrospective character. RESULTS. 30 women showed a raised concentration of CRP and 13 – of PCT. No correlation was found between the two diagnostic markers. Similarly, no relation was found between a raised concentration of PCT and the occurrence of a bacterial infection or other complications in the parturient. A raised concentration of procalcitonin in the mother did not translate into the development of an infection in the newborn, either. CONCLUSIONS. The results of the study indicate that there is no correlation between a raised concentration of PCT in GBS-positive pregnant women and a raised CRP level. Abnormal PCT levels in the women covered by the study did not involve a higher frequency of the occurrence of complications or bacterial infections either in the mothers or in the newborns.