Oral amyloidosis: A strategy to differentiate systemic amyloidosis involving the oral cavity and localized amyloidosis.

Amyloidosis is a rare metabolic disorder caused by the extracellular deposition of fibrillar proteins in important organs. The prognosis of oral amyloidosis associated with systemic involvement is generally poor, but is much more favourable in localized cases. Limited information is available regarding the differential diagnosis between localized and systemic amyloidosis involving the oral mucosa, and also the prognosis. In this study, we summarize the strategy for correctly discriminating between localized and systemic oral amyloidosis, to give the right advice during the diagnostic workup.