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Detoxification process of tolaasins, lipodepsipeptides, by Microbacterium sp. K3-5.
Bioscience, Biotechnology, and Biochemistry 2018 August
Tolaasins are antimicrobial lipodepsipeptides. Here, we report the tolaasins-detoxifying properties of Microbacterium sp. K3-5 (K3-5). The detoxification of tolaasins by K3-5 was performed by hydrolyzation of cyclic structure of tolaasins depending on the tolaasin-K3-5 cell interaction. Our data suggest that the cyclic structure of tolaasins is critical for its interaction to target cells.
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