Factors associated with unplanned extubation in the Intensive Care Unit for adult patients: A systematic review and meta-analysis.

OBJECTIVES: To explore factors associated with unplanned extubation in Intensive Care Unit for adult patients.

RESEARCH METHODOLOGY: A systematic review and meta-analysis were performed of studies identified through Pubmed, CINAHL, Cochrane Library, PsycINFO and Web of Science published from initiation to September 2017. Only articles in English were included. The Newcastle-Ottawa Scale was used to evaluate the quality of the included articles.

RESULTS: Ten eligible studies were identified, encompassing a total of 2092 patients (457 in the unplanned extubation group; 1635 in the control group). The subsequent meta-analysis identified significant risk factors for unplanned extubation are male [odds ratio (OR) 1.54, 95% CI 1.12-2.12; P = 0.008], confusion [OR 0.10, 95% CI 0.05-0.17; P < 0.00001], physical restraint [OR 3.10, 95% CI 2.21-4.34; P < 0.00001], higher GCS scores [mean difference (MD) 1.06, 95% CI 0.59-1.52; P < 0.00001] and lower APACHE II scores [MD -2.26, 95% CI -3.35- -1.16; P < 0.0001]. Renal disease is a protective factor for unplanned extubation [OR 0.32, 95% CI 0.15-0.70; P = 0.004].

CONCLUSION: Patients were male, confused, having physical restraint, with higher GCS and lower APACHE II scores are significant risk factors for unplanned extubation in Intensive Care Unit adult patients.