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CASE REPORTS
JOURNAL ARTICLE
[A weak D type 59 case identified in the Chinese Han population].
Zhonghua Yi Xue Yi Chuan Xue za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics 2018 April 11
OBJECTIVE: To study a case with weak D59 phenotype identified among ethnic Han Chinese population.
METHODS: Routine serological tests were used to analyze the reaction patterns, and the RhD epitopes were verified with 12 monoclonal antibodies. Sequence-specific primer PCR was applied for typing the weak RhD and RhD zygosity in the proband and his family members.
RESULTS: A c.1148T>C variant was identified in the proband, for which serological test indicated a weak D phenotype. RHD zygosity testing confirmed that the proband had a RHD+ /RHD- genotype.
CONCLUSION: A weak D59 phenotype was firstly identified in a Chinese individual.
METHODS: Routine serological tests were used to analyze the reaction patterns, and the RhD epitopes were verified with 12 monoclonal antibodies. Sequence-specific primer PCR was applied for typing the weak RhD and RhD zygosity in the proband and his family members.
RESULTS: A c.1148T>C variant was identified in the proband, for which serological test indicated a weak D phenotype. RHD zygosity testing confirmed that the proband had a RHD+ /RHD- genotype.
CONCLUSION: A weak D59 phenotype was firstly identified in a Chinese individual.
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