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Phage Aggregation-Dispersion by Ions: Striving beyond Antibacterial Therapy.

Marek Drab
Trends in Biotechnology 2018 September
Bacteriophages sense alkaline cations in their immediate extracellular environment, which regulates virion-virion interactions. An ion-steerable aggregation-dispersion (A/D) phenomenon among virions is a recently discovered step in group behavior in the phage life cycle. When powered by the octanol-based water-immiscible lipopolysaccharide (LPS) trap (oWILT) purification approach, A/D promises breakthroughs for a plethora of biotechnological applications beyond phage therapy.

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