We have located links that may give you full text access.
Chitosan nanoparticles as a biocompatible and efficient nanowagon for benzyl isothiocyanate.
A plethora of evidences support the health benefits of a sulfur containing compound called Benzyl Isothiocyanate. However, its therapeutic application is limited due to its low solubility, poor stability and inadequate bioavailability. The problem has been worked upon and resolved by the synthesis of biodegradable nanoparticles using chitosan as the controlled delivery nanowagon. The prepared nanoparticles have been characterized using UV-visible absorption spectroscopy, IR spectroscopy, XRD, TGA, TEM and FE-SEM. Results reveal that loading of benzyl isothiocyanate into chitosan nanoparticles increases its solubility and stability. The maximum encapsulation efficiency was obtained to be 64.68±4.7% with slow and sustained release of 77.78% in 144h at pH5.5. Clear enhancement in the stability of benzyl isothiocyanate that is sensitive to ultraviolet light has been showcased after its encompassment in the cationic polymer. Further the biosafety of the fabricated system has been demonstrated by haemolysis and its interaction with biomolecules. The antimicrobial activity connotes that the prepared nanoparticles can act as a useful and safe carrier for the loading of benzyl isothiocyanate making it a promising formulation for biological applications in future.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app