Gastric cancer increases transmigratory potential of peripheral blood monocytes by upregulation of β1- and β2-integrins.

Introduction: Immune responses within the tumor depend on the ability of leukocytes to migrate from peripheral circulation into the local microenvironment. This process is controlled by mechanisms that guide leukocytes to the side of inflammation, allowing them to cross vascular endothelial barrier. Monocytes/macrophages are the predominant population of leukocyte infiltrate of many tumors, including, gastric cancer. However, to date mechanisms that control monocyte trafficking to the side of tumor growth are not fully elucidated.

Aim of the study: It this study we aimed to evaluate transmigratory potential of peripheral blood monocytes from gastric cancer patients.

Material and methods: By using multicolor flow cytometry we assessed expression of β1- and β2-integrins on peripheral blood monocytes from gastric cancer patients.

Results: We found increased frequencies of VLA-4 and VLA-6 expressing monocytes and increased expression of analyzed β2-integrins in gastric cancer patients when compared to age matched controls.

Conclusions: In summary, this study revealed that gastric cancer increases transmigratory potential of peripheral blood monocytes.