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Structure and Functions of the Mediator Complex.

E V Putlyaev, A N Ibragimov, L A Lebedeva, P G Georgiev, Y V Shidlovskii
Biochemistry. Biokhimii︠a︡ 2018 April
Mediator is a key factor in the regulation of expression of RNA polymerase II-transcribed genes. Recent studies have shown that Mediator acts as a coordinator of transcription activation and participates in maintaining chromatin architecture in the cell nucleus. In this review, we present current concepts on the structure and functions of Mediator.

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