The evolution of eccrine sweat gland research towards developing a model for human sweat gland function.

For several decades now, researchers, professional bodies, governments and journals such as the journal of Experimental Dermatology, have worked to reduce the number of animals used in experimentation. This review centers on investigations into how human sweat glands produce sweat and how that research has evolved over the years. It is hoped that this review will show, that as methodologies advanced, sweat gland research has come to rely less and less on a variety of animal models as investigative tools and information is being primarily obtained through human and mouse material, with a view to further reductions in using animal models. This article is protected by copyright. All rights reserved.