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Building Bonds: Cancer Stem Cells Depend on Their Progeny to Drive Tumor Progression.

Sree Deepthi Muthukrishnan, Alvaro G Alvarado, Harley I Kornblum
Cell Stem Cell 2018 April 6
Little is currently known about how cancer stem-like cells (CSCs) interact with their more restricted progeny. In this issue of Cell Stem Cell, Wang et al. (2018) demonstrate a novel bidirectional signaling axis between CSCs and their progeny that is mediated by brain-derived neurotrophic factor and VGF accelerating glioma progression.

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