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Journal Article
Review
Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity.
Journal of Applied Toxicology : JAT 2018 April 7
This review describes the synthesis of a wide range of novel tetrahydroacridine derivatives (tiocyanates, selenocyanates, ureas, selenoureas, thioureas, isothioureas, disulfides, diselenides and several tacrine homo- and hetro-hybrids). These tacrine congeners exhibit significant anticholinesterase and cytotoxic properties and may therefore be of considerable potential for the development of new drugs for the treatment of Alzheimer's disease.
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