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Journal Article
Research Support, N.I.H., Extramural
Review
A review of salvinorin analogs and their kappa-opioid receptor activity.
Bioorganic & Medicinal Chemistry Letters 2018 May 16
The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid receptor, an emerging target for next-generation analgesics. Here we review analogs of the salvinorin chemotype and their effects on selectivity, affinity and potency. Extensive peripheral modifications using isolated salvinorin A have delivered a trove of SAR information. More deep-seated changes are now possible by advances in chemical synthesis.
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