We have located links that may give you full text access.
Selenium-Rich Yeast Protects Against Aluminum-Induced Renal Inflammation and Ionic Disturbances.
Biological Trace Element Research 2018 December
The aim of this study was to evaluate the protective effects of SeY (selenium-rich yeast) against Al (aluminum)-induced inflammation and ionic imbalances. Male Kunming mice were treated with Al (10 mg/kg) and/or SeY (0.1 mg/kg) by oral gavage for 28 days. The degree of inflammation was assessed by mRNA expression of inflammatory biomarkers. Ionic disorders were assessed by determining the Na+ , K+ , and Ca2+ content, as well as the alteration in ATP-modifying enzymes (ATPases), including Na+ K+ -ATPase, Ca2+ -ATPase, Mg2+ -ATPase, Ca2+ Mg2+ -ATPase, and the mRNA levels of ATPase's subunits in kidney. It was observed here that SeY exhibited a significant protective effect on the kidney against the Al-induced upregulation of pro-inflammatory and downregulation of anti-inflammatory cytokines. Furthermore, a significant effect of Al on the Na+ , K+ , Ca2+ , and Mg2+ levels in kidney was observed, and Al was observed to decrease the activities of Na+ K+ -ATPase, Mg2+ -ATPase, and Ca2+ Mg2+ -ATPase. The mRNA expression of the Na+ K+ -ATPase subunits and Ca2+ -ATPase subunits was regulated significantly by Al. Notably, SeY modulated the Al-induced alterations of ion concentrations, ATPase activity, and mRNA expression of their subunits. These results suggest that SeY prevents renal toxicity caused by Al via regulation of inflammatory responses, ATPase activities, and transcription of their subunits.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app