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Long-Standing Ulcerative Colitis May Trigger a Multilineage Cancerization Field.

Matteo Fassan, Stefano Brignola, Giacomo Sarzo, Rocco Cappellesso, Massimo Rugge
International Journal of Surgical Pathology 2018 September
Longstanding/relapsing inflammation characterizing ulcerative colitis (UC) has been associated to an increased risk of colon mucosa neoplastic transformation. We describe the clinicopathological features of a UC-related poorly-differentiated neuroendocrine carcinoma coexisting with a conventional adenocarcinoma. This case supports UC as a multilineage cancerization field.

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