We have located links that may give you full text access.
Optic disc-fovea distance and myopia progression in school children: the Beijing Children Eye Study.
Acta Ophthalmologica 2018 August
PURPOSE: To assess changes in the optic disc-fovea distance (DFD) with progressing myopia in school children.
METHODS: The school-based, prospective, longitudinal study included grade-1 children in 2011 who were yearly re-examined until 2016. We measured DFD, optic disc diameters and width of parapapillary gamma zone (parapapillary region without Bruch's membrane (BM)) on fundus photographs.
RESULTS: Of 382 grade-1 children examined in 2011, 294 (77.0%) children (mean age in 2011: 6.4 ± 0.5 years) returned to be examined in 2016. In relative terms, the increase in DFD (1.15 ± 0.33 mm) was more due to an increase in gamma zone width (+300% or 0.29 ± 0.30 mm) than an increase in macular BM length (+18% or 0.74 ± 0.21 mm). In multivariate regression analysis, longer increase in DFD was correlated (regression coefficient r2 = 0.79) with longer axial elongation during the study period (p < 0.001; standardized regression coefficient β: 0.61; non-standardized regression coefficient B: 0.30; 95% confidence interval (CI): 0.26, 0.33), larger increase in gamma zone width (p < 0.001; β: 0.35; B: 0.40; 95%CI: 0.32, 0.48) and longer axial length in 2011 (p = 0.01; β:0.07; B:0.03; 95%CI:0.01, 0.06). Larger increase in gamma zone width was associated (r2 = 0.73) with larger increase in DFD (p < 0.001; β: 0.51; B: 0.46; 95%CI: 0.39, 0.53), larger increase in the vertical-to-horizontal disc diameter ratio (p < 0.001; β: 0.43; B:1.21; 95%CI: 1.00, 1.42) and longer vertical disc diameter (p < 0.001; β: 0.15; B:0.24; 95%CI: 0.14, 0.34).
CONCLUSION: In adolescent school children, axial elongation-associated increase in DFD was mainly due to an enlargement (+300%) of parapapillary gamma zone, while macular BM length increased to minor degree (+18%). Gamma zone enlargement was correlated with axial elongation-associated vertical optic disc rotation, potentially due to an increased backward pull of the optic nerve on the temporal optic disc border.
METHODS: The school-based, prospective, longitudinal study included grade-1 children in 2011 who were yearly re-examined until 2016. We measured DFD, optic disc diameters and width of parapapillary gamma zone (parapapillary region without Bruch's membrane (BM)) on fundus photographs.
RESULTS: Of 382 grade-1 children examined in 2011, 294 (77.0%) children (mean age in 2011: 6.4 ± 0.5 years) returned to be examined in 2016. In relative terms, the increase in DFD (1.15 ± 0.33 mm) was more due to an increase in gamma zone width (+300% or 0.29 ± 0.30 mm) than an increase in macular BM length (+18% or 0.74 ± 0.21 mm). In multivariate regression analysis, longer increase in DFD was correlated (regression coefficient r2 = 0.79) with longer axial elongation during the study period (p < 0.001; standardized regression coefficient β: 0.61; non-standardized regression coefficient B: 0.30; 95% confidence interval (CI): 0.26, 0.33), larger increase in gamma zone width (p < 0.001; β: 0.35; B: 0.40; 95%CI: 0.32, 0.48) and longer axial length in 2011 (p = 0.01; β:0.07; B:0.03; 95%CI:0.01, 0.06). Larger increase in gamma zone width was associated (r2 = 0.73) with larger increase in DFD (p < 0.001; β: 0.51; B: 0.46; 95%CI: 0.39, 0.53), larger increase in the vertical-to-horizontal disc diameter ratio (p < 0.001; β: 0.43; B:1.21; 95%CI: 1.00, 1.42) and longer vertical disc diameter (p < 0.001; β: 0.15; B:0.24; 95%CI: 0.14, 0.34).
CONCLUSION: In adolescent school children, axial elongation-associated increase in DFD was mainly due to an enlargement (+300%) of parapapillary gamma zone, while macular BM length increased to minor degree (+18%). Gamma zone enlargement was correlated with axial elongation-associated vertical optic disc rotation, potentially due to an increased backward pull of the optic nerve on the temporal optic disc border.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app