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COMMENT
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Sterile Inflammation Fuels Gastric Cancer.
Immunity 2018 March 21
Constitutively activated NF-κB signaling has long been known to be oncogenic. In this issue of Immunity, O'Reilly et al. (2018) unveil a link between loss of NF-κB1, aberrant STAT1 signaling, sterile inflammation, and the increased expression of immune checkpoint molecules as cancer drivers.
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