Simultaneous multiparametric PET/MRI for the assessment of therapeutic response to chemotherapy or concurrent chemoradiotherapy of cervical cancer patients: Preliminary results.

Theresia Sarabhai, Alexander Tschischka, Vanessa Stebner, Felix Nensa, Axel Wetter, Rainer Kimmig, Michael Forsting, Ken Herrmann, Lale Umutlu, Johannes Grueneisen

Clinical Imaging 2018 May

PURPOSE: To assess the response to initial treatment strategies of cervical cancer using multiparametric-PET/MRI.

MATERIAL AND METHODS: PET/MR-derived morphological (tumor size), functional (DWI, DCE-MRI) and metabolic (18F-FDG PET) parameters were acquired in pre- and posttreatment examinations of 8 patients. Besides RECIST- and PERCIST-criteria, functional quantitative parameters were used to assess therapeutic response.

RESULTS: RECIST- and PERCIST-response criteria demonstrated high correlations for the differentiation between therapy-responders and non-responders, which was additionally reflected by functional (DWI, DCE-MRI) quantitative imaging parameters.

CONCLUSION: Multiparametric-PET/MRI bears the potential of a more comprehensive response assessment of initial treatment strategies in cervical cancer patients.

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