[EVALUATIONS OF SENSORY ATTRIBUTE OF INTRANASAL CORTICOSTEROID SPRAYS IN HEALTHY VOLUNTEERS].

BACKGROUND: Intranasal corticosteroid sprays (INCSs) have not been a mainstay of the treatment for nasal allergies. We evaluated the sensory effects of INCSs since they might affect compliance to treatment.

METHODS: The study population included 45 healthy volunteers. The subjects were randomized 1 : 1 to receive fluticasone furoate (FF) followed by mometasone furoate (MF) or MF followed by FF. There was a 30-minutes waiting period between the administration of each drug. The subjects completed questionnaire to evaluate the nasal sprays immediately after and 2 or 3 minutes after the drug administration.

RESULTS: The subject favored FF over MF. A logistic regression analysis showed that nasal irritation was a significant effect after the use of FF and MF. The sensory effects of FF and MF were not unfavorable to the extent that they affect daily use.

CONCLUSION: The sensory effects of INCSs were not as unfavorable as we thought.