Susceptibility and severity of cancer-related fatigue in colorectal cancer patients is associated with SLC6A4 gene single nucleotide polymorphism rs25531 A>G genotype.

PURPOSE: To explore the correlation between the SERT gene promoter single nucleotide polymorphisms (SNPs) rs25531 and rs956304 and the cancer-related fatigue (CRF) of colon and rectal cancer, and also to analyze the correlation of the interaction of genetic and non-genetic factors.

METHOD: A sample of 568 colon and rectal cancer patients were recruited from the Second Affiliated Hospital of Nanchang University from October 2013 to December 2015. The Chinese version of the Brief Fatigue Inventory (BFI-C) was used to evaluate the CRF. The genomic DNA was extracted from peripheral blood samples of the patients. Direct sequencing was used to determine the rs25531 and rs956304 genotypes.

RESULTS: Compared with the AA genotype, the risk of suffering from CRF and the severity of CRF increased to 1.77 times (95% CI = 1.22-2.59, P = 0.003) for patients who carry with G allele (AG+GG genotype) at rs25531 locus.

CONCLUSIONS: The SERT gene promoter SNP rs25531 was associated with the CRF in patients with colon and rectal cancer and the G genotype was an independent risk factor for CRF among individuals with colon and rectal cancer in the study.