Synergistic effect of 1-butyl-2,3-dimethylimidazolium bis (trifluoromethanesulfonyl) imide and titanium oxide on the redox behaviour of flunarizine in solubilized media.

Titanium oxide nanoparticles and 1-butyl-2,3-dimethylimidazolium bis (trifluoromethanesulfonyl) imide modified glassy carbon electrode (TiO2 /IL/GCE) has been fabricated for electrochemical sensing of flunarizine (FRH). The electrochemical properties and morphology of the prepared nanocomposite were studied by electrochemical impedance spectroscopy (EIS) and transmission electron microscopy (TEM). The response of the electrochemical sensor was found to be proportional to the concentrations of FRH in the range from 0.5 μgmL-1 to 16 μgmL-1 . The detection limit obtained was 0.03 μgmL-1 . The proposed method was also applied to the determination of FRH in pharmaceutical formulation and human serum with good recoveries.