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Journal Article
Research Support, Non-U.S. Gov't
Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton.
Bioorganic & Medicinal Chemistry 2018 May 2
The estrogen receptor (ER), a member of the nuclear receptor (NR) family, is involved in the regulation of physiological effects such as reproduction and bone homeostasis. Approximately 70% of human breast cancers are hormone-dependent and ERα-positive, and, thus, ER antagonists are broadly used in breast cancer therapy. We herein designed and synthesized a set of ER antagonists with a 4-heterocycle-4-phenylheptane skeleton.
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