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Goldilocks Dosing of TKIs: A Dose that Is Just Right Leads to Optimal Outcomes.
Clinical Cancer Research 2018 July 2
Higher concentrations of TKIs, such as pazopanib, are associated with improved outcomes in advanced RCC. A phase III trial failed to show disease-free survival benefit to pazopanib in the adjuvant setting, but improved DFS was seen in patients with higher C trough levels, supporting adequate drug exposure for optimal clinical outcome. Clin Cancer Res; 24(13); 2979-80. ©2018 AACR See related article by Sternberg et al., p. 3005 .
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