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Hydrogen-Borrowing Alcohol Bioamination with Coimmobilized Dehydrogenases.
ChemCatChem 2018 Februrary
The amination of alcohols is an important transformation in chemistry. The redox-neutral (i.e., hydrogen-borrowing) asymmetric amination of alcohols is enabled by the combination of an alcohol dehydrogenase (ADH) with an amine dehydrogenase (AmDH). In this work, we enhanced the efficiency of hydrogen-borrowing biocatalytic amination by co-immobilizing both dehydrogenases on controlled porosity glass FeIII ion-affinity beads. The recyclability of the dual-enzyme system was demonstrated (5 cycles) with total turnover numbers of >4000 and >1000 for ADH and AmDH, respectively. A set of ( S )-configured alcohol substrates was aminated with up to 95% conversion and >99% ee ( R ). Preparative-scale amination of ( S )-phenylpropan-2-ol resulted in 90% conversion and 80% yield of the product in 24 h.
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