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High Cholesterol at the Heart of Phagolysosomal Damage.

Andrew P Lieberman, Joel A Swanson
Cell Metabolism 2018 March 7
Phagolysosome membrane rupture can trigger a maladaptive immune response that promotes tissue damage. In Science, Cantuti-Castelvetri et al. (2018) report that cholesterol-rich myelin debris overwhelms reverse cholesterol transport in aged phagocytes, leading to cholesterol crystal formation, damaged phagolysosomes, and limited tissue repair.

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