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Journal Article
Review
Treatment with growth hormone in the prader-willi syndrome.
Endocrinología, diabetes y nutrición. 2018 April
INTRODUCTION: The Prader-Willi syndrome (PWS) is a rare genetic disorder caused by absence of expression of the paternal alleles in región 15q11.2-q13. Obesity and hormonal deficiencies, especially of growth hormone (GH), are the most important signs from the therapeutic viewpoint. Recombinant GH (rGH) is effective in children and represents the mainstay in treatment; by contrast, little evidence in available in adult patients.
OBJECTIVE: To review the reported evidence on the beneficial and adverse effects of treatment with rGH in children and adults.
DESIGN: A review was made of 62 original articles published between 2000 and 2017 using the PubMed database.
RESULTS: In pediatric and adult PWS, rGH improves body morphology and composition, physical performance, cognition, psychomotor development, respiratory function, and quality of life with few adverse effects.
CONCLUSIONS: Treatment with rGH is effective and safe and improves quality of life in both children and adults with PWS.
OBJECTIVE: To review the reported evidence on the beneficial and adverse effects of treatment with rGH in children and adults.
DESIGN: A review was made of 62 original articles published between 2000 and 2017 using the PubMed database.
RESULTS: In pediatric and adult PWS, rGH improves body morphology and composition, physical performance, cognition, psychomotor development, respiratory function, and quality of life with few adverse effects.
CONCLUSIONS: Treatment with rGH is effective and safe and improves quality of life in both children and adults with PWS.
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