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MiR-126 functions as a tumor suppressor by targeting SRPK1 in human gastric cancer.

Oncology Research 2018 Februrary 9
The expression of miR-126 and serine-arginine protein kinase 1 (SRPK1) are linked to tumor development; nevertheless, its role in tumor growth and invasion of gastric cancer (GC) and the underlying mechanism has not been clarified. Here, the expression and role of miR-126 and SRPK1 was investigated in GC tissues and cells by in-vitro assay, and then targets of miR-126 were identified by dual-luciferase reporter assay. In this study, miR-126 expression was downregulated, and associated with lymph node metastasis and poor prognosis as well as SRPK1 expression. In vitro assay revealed that miR-126 obviously inhibited proliferation and invasive capability of GC cells. Dualluciferase reporter assay showed that miR-126 targets 3'-UTR of SRPK1 and downregulates its expression. Besides, SRPK1 over-expression promoted cell migration and invasion. In conclusion, we identified that miR-126 suppresses tumor growth and metastasis in GC by targeting SRPK1. The expression of miR-126 suggests GC recurrence and metastasis, which shed crucial light on how miR-126 functions in GC pathogenesis.

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