The relationship between IGF-2, IGFBP-2, and IGFBP-3 levels in patients suffering from pre-diabetes.

Many studies have shown that intervention in the early stages of diabetes may have a pivotal role in reducing the risk of cardiovascular diseases. This study was designed to assess possible relationships between insulin-like growth factor 2 (IGF-2), insulin-like growth factor binding proteins 2 and 3 (IGFBP-2, IGFBP-3) and pre-diabetes. A total of sixty clinically ascertained pre-diabetes cases and twenty-five healthy controls were included. Serum IGF-2 and binding proteins were estimated using commercially available ELISA kit. All groups had a positive correlation between all serum parameters. Multinomial logistic regression showed that all the study parameters directly affected each other. The results could not prove any correlation between IGF-2 and its binding proteins during pre-diabetes stage. Further assessments of these factors in larger groups of males and females in diabetic individuals could be useful to support our hypothesis that these factors change only in diabetes mellitus.